Hope for cancer patients: Enzyme linked to colon cancer identified

Hope for cancer patients: Enzyme linked to colon cancer identified

Researchers have identified an enzyme that appears to drive the conversion of normal colon tissue into cancer by attaching sugar molecules, or glycans, to certain proteins in the cell. The research, published in the Journal of Biological Chemistry, showed that the enzyme was absent in healthy colon tissue but abundant in colon cancer cells. “Our data suggest (that) this specific enzyme seems to affect a subset of proteins that could be involved in cell-cell adhesion,” said Hans Wandall from University of Copenhagen in Denmark. In other words, the glycan modifications…

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Altered DNA linked with psychiatric disorders identified

Altered DNA linked with psychiatric disorders identified

Brain scans have revealed a genetic mutation that affects the structure, function and chemistry of the brain, and thus increases the risk of major psychiatric disorders like schizophrenia, bipolar disorder and depression, says a research. The findings showed that the people with the DISC1 mutation caused a part of one chromosome to swap places with another as well as lead to changes in the structure of their brain. These changes were associated with a significant increase in the risk of psychiatric illness, the researchers said. “The study confirms and extends…

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Protein that may ‘shock and kill’ HIV virus identified

Protein that may ‘shock and kill’ HIV virus identified

  Researchers have identified a protein that can potently force the latent human immunodeficiency virus (HIV) viruses out of hiding and poison them on their way out, leading to potential treatments for the deadly disease. The findings showed that galectin-9 — a human sugar-binding protein — reactivates latent HIV viruses and renders these infected cells visible to the immune system, in a process called the “shock and kill” HIV eradication strategy. Galectin-9 works by manipulating the sugars on the surface of HIV-infected cells to deliver the signals that force latent…

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