Rare Skin Reactions after mRNA Vaccination, Similar to Jones–Mote Basophil Responses

In a small group of recipients of messenger RNA (mRNA) vaccines against coronavirus disease 2019 (Covid-19), the occurrence of erythematous and indurated skin reactions has been reported at an average of 8 days after the first or second injection.1 The identification of such hypersensitivity responses has been a focus of study for many years by researchers investigating various systems. Such reactions to mRNA vaccines strongly resemble the primary first-dose flare and secondary skin-test responses that we reported 45 years ago in volunteers who were injected with foreign proteins2 (Figure 1A). At that…

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